Polymeric vesicle formation via temperature-assisted nanoprecipitation
نویسندگان
چکیده
We here report an easy and efficient strategy to prepare submicron-sized polymeric vesicles with tetrahydrofuran (THF) as a good solvent through temperature-assisted nanoprecipitation (TAN). While conventional nanoprecipitation did not yield vesicles from block co-polymers (PEG-b-PCL), TAN produced vesicles with morphology and membrane thickness similar to those obtained by film rehydration method. Elevated temperature to allow fast evaporation of THF was identified to be the key process parameter of TAN.
منابع مشابه
Nanoprecipitation of polymeric nanoparticle micelles based on 2-methacryloyloxyethyl phosphorylcholine (MPC) with 2-(diisopropylamino)ethyl methacrylate (DPA), for intracellular delivery applications
Biodistribution of nanoparticle-based intracellular delivery systems is mediated primarily by particle size and physicochemical properties. As such, overcoming the rapid removal of these by the reticuloendothelial system remains a significant challenge. To date, a number of copolymer nanoparticle systems based on 2-methacryloyloxyethyl phosphorylcholine (MPC) with 2-(diisopropylamino)ethyl meth...
متن کاملModifications to the conventional nanoprecipitation technique: an approach to fabricate narrow sized polymeric nanoparticles.
PURPOSE Nanoprecipitation is the convenient and commonly used method for the preparation of polymeric nanoparticles around 170 nm but yield particles with broad distribution, which require filtration step to produce particles with narrow distribution. Hence, the primary aim of the present study was to implement few modifications to the conventional nanoprecipitation method to reduce the mean pa...
متن کاملNovel Synthesis of Polymeric Nanoparticles for Drug Delivery Applications Using Microfluidic Rapid Mixing
We report the use of microfluidic rapid mixing using hydrodynamic flow focusing to control the self-assembly of polymeric nanoparticles (NPs) that can be used for drug delivery. PLGA-PEG polymeric NPs and PLGA-lipid hybrid NPs were synthesized through nanoprecipitation—a process that involves dilution of a block copolymer from a solvent to an anti-solvent resulting in the precipitation of NPs. ...
متن کاملRedox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.
We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration...
متن کاملPreparation of protein-loaded PLGA-PVP blend nanoparticles by nanoprecipitation method: entrapment, Initial burst and drug release kinetic studies
Objective(s):Despite of wide range applications of polymeric nanoparticles in protein delivery, there are some problems for the field of protein entrapment, initial burst and controlled release profile. Materials and Methods: In this study, we investigated the influence of some changes in PLGA nanoparticles formulation to improve the initial and controlled release profile. Selected parameters ...
متن کامل